Abstract: The East China Sea Shelf Basin is the largest marginal basin in China's offshore waters. Its underground geological structure is relatively complex and thus the quality of mid-deep seismic data is poor. Conventional seismic wave energy compensation technology is not efficient enough to obtain effective stratigraphic information and the research of mid-deep structure and the exploration of mid-deep oil and gas are restricted in the East China Sea. In order to solve the problem, this paper introduced the method of formation Q-value compensation method based on wavelet frequency division. This method focuses on the target layer and divides the seismic data into frequency segments so as to avoids the mutual influence of seismic signals from different frequency components, so that the frequency information of the target layer might be better treated. As the result, the stability of formation Q value extraction is improved. Finally, the amplitude and phase compensation of target layer Q value are performed. The model and examples show that this method can effectively compensate the deep seismic data in the East China Sea, improve the main frequency, broaden the frequency band, and thus improve the quality of seismic data, which is favorable for inversion of seismic data.