Abstract: Based on the analysis of OC, P, Ba, Mn, S, K₂O, Pb, As, Al₂O₃, Fe₂O₃, and Cu contents and magnetic susceptibility of sediment in Changning site, Qinghai Province, responses of the elemental contents to human activity and climate change during late Holocene have been discussed. The result indicated that climatic degeneration between Qijia cultural period (4 300~3 900 aBP)and Han Dynasty(202 BC~220 AD) made elemental contents in the sediment drop significantly, human activities in Qijia cultural period and Han Dynasty also affected these elemental contents, and the impact of human activities varied due to different land uses.