Abstract: The episodic characteristics of fault activity and their effects on the sedimentary and structural evolution during Paleogene are revealed based on analysis of sedimentation history in the Dongpu Depression. It is suggested that (1)the fault activity during Paleogene can be divided into five episodes, i.e. early activity phase (Es₄), rapid activity phase (Es₃⁴), slow activity phase (Es₃³), reactivation phase (Es₃²-Es₂²),and senescent phase (Es₂¹-Ed); (2)The episodes of the fault activity directly controlled Order-Ⅲ sequence surface and sedimentary evolution; (3)The episodes of the fault activity directly controlled the structural evolution in the basin, forming early activity phase (Es₄), rapid activity phase (Es₃⁴), slow activity phase (Es₃³), reactivation phase (Es₃²-Es₂²) and senescent phase (Es₂¹-Ed).